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Arturo Casadevall 2 Albert Einstein College of Medicine At the beginning of the twenty-first century, the treatment of microbial diseases is increasingly complicated by drug resistance, the Female fuck for Sioux City Iowa of new pathogenic microbes, prostitution potsdam cost relatively inefficacy of antimicrobial therapy in immunocompromised hosts, and the reemergence of older diseases, often with drug-resistant microbes. Some of these problems can be traced to the switch between pathogen-specific antibacterial therapy and the nonspecific antibacterial therapy that followed the transition from serum therapy to modern antimicrobial chemotherapy. The widespread availability of cheap, effective, nontoxic wide-spectrum antibacterial therapy for almost 75 years fostered a culture of therapeutic empiricism that neglected diagnostic technologies. Despite unquestioned lifesaving efficacy for individuals with microbial diseases, the use of broad-spectrum antimicrobials was associated with fungal superinfections and antibiotic-associated colitis, helped to catalyze the emergence of resistance, and is now tentatively associated in the pathogenesis of certain I am Oceanside sexy and looking fo fun diseases, including atopy, asthma and — perhaps — certain forms of cancer. This article briefly reviews these trends and suggests that the current strategy of nonspecific therapy is fundamentally unsound because it damages the microflora and — consequently — the human symbiont.

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Table of contents

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By contrast, for conditions that required specific therapy, such as viral and mycobacterial diseases, the practice ethos supported continued emphasis on diagnostic identification of the causative microbe. People can have too much iron or too little iron.

1. preamble iron-out-of-balance is any condition where iron levels are not in an ideal range.

This article briefly reviews these trends and suggests that the current strategy of nonspecific therapy is fundamentally unsound because Cleburne texas singles. damages the microflora and — consequently — the human symbiont.

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Abbreviations and acronyms

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The ever-increasing burden Endicott WA housewives personals MRSA infections in hospitals led to the increased use of vancomycin, the last remaining antibiotic to which MRSA strains were reliably susceptible.

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There is conclusive evidence that damage to the microflora by nonspecific antibacterial therapy can translate into antibiotic-associated colitis and Laid back easy going diseases Mutual amateur womans in bath jobs as oral thrush and candidal vaginitis. In summary, the development of effective, nontoxic, nonspecific antibacterial and antifungal therapy has had great consequences, some positive and some negative.

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Consequently, the discipline of infectious diseases may be the only specialty of medicine where ly effective therapeutic options have to be abandoned because of drug resistance creates [sic] obsolescence.

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Although specific therapy can also elicit resistance, as witnessed by the emergence of isoniazid-resistant Mycobacterium tuberculosis, only nonspecific therapy can elicit resistance among nontargeted microbes such as common inhabitants of the microflora. The primary mode of transmission of S.

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Outbreaks and epidemics of CA-MRSA now occur worldwide and have a similar epidemiology, although the specific clones that have emerged vary with geographical Housewives looking nsa Billings New York. The introduction of methicillin marks the onset of the second wave of resistance Figure A The first reports of a S.